ea0086p97 | Neuroendocrinology and Pituitary | SFEBES2022
Benjamin Loughrey Paul
, Suleyman Oniz
, Begalli Federica
, Craig Stephanie G
, Hunter Steven J
, McArt Darragh G
, James Jacqueline A
, Haworth Oliver
, Barry Sayka
, Korbonits Marta
Background: The cyclic GMP-AMP synthase stimulator of interferon genes (cGAS-STING) signalling pathway is an element of the innate immune response and is activated by the presence of DNA in the cytosol. Triggering of this immune response may occur in the setting of infection or neoplasia. Activation of this pathway results in phosphorylation of interferon regulatory factor 3 and downstream transcription of cytokines such as interferon β and interleukin-6. Polyinosinic:pol...